Adverse Occurrence type:
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
27 year old male developed headache, vomiting'altered mental status, seizures and ring enhancing lesions in brain by MRI with onset 10 days after kidney transplantation. Spinal fluid showed B. mandrillaris. He died after 2 months in coma
Demonstration of imputability or root cause:
Certain. Recipient and donor were infected by B mandrillaris. Donor was a young boy who had a transient febrile illness diagnosed as infulenza type A. A week later he had a sudden headache and seizure. Seizures were recurrent , leading to a subarachnoid hemorrhage, brain swelling herniation and death 15 days after his onset of headache. He was diagnosed ADEM but autopsy showed brain ameba infection. Two kidneys, liver and heart were donated. Heart and liver recipients received preemptive treatment and did not get infected.
Transmission of Balamuthia mandrillaris through solid organ transplantation: utility of organ recipient serology to guide clinical management.
Balamuthia mandrillaris meningoencephalitis associated with solid organ transplantation--review of cases.
Emerging trends in free-living amebic infections of the brain: implications for organ transplantation.