Policy Statement-Children as Hematopoietic Stem Cell Donors

TitlePolicy Statement-Children as Hematopoietic Stem Cell Donors
Publication TypeJournal Article
Year of Publication2010
AuthorsDiekema DS, Fallat M, Antommaria AH, Holzman IR, Katz AL, Leuthner SR, Ross LF, Webb SA
Pagination392 - 404
Date PublishedFeb
Accession NumberISI:000275942900026

In the past half-century, hematopoietic stem cell transplantation has become standard treatment for a variety of diseases in children and adults, including selected hematologic malignancies, immunodeficiencies, hemoglobinopathies, bone marrow failure syndromes, and congenital metabolic disorders. There are 3 sources of allogeneic hematopoietic stem cells: bone marrow, peripheral blood, and umbilical cord blood; each has its own benefits and risks. Children often serve as hematopoietic stem cell donors, most commonly for their siblings. HLA-matched biological siblings are generally preferred as donors because of reduced risks of transplant-related complications as compared with unrelated donors. This statement includes a discussion of the ethical considerations regarding minors serving as stem cell donors, using the traditional benefit/burden calculation from the perspectives of both the donor and the recipient. The statement also includes an examination of the circumstances under which a minor may ethically participate as a hematopoietic stem cell donor, how the risks can be minimized, what the informed-consent process should entail, the role for a donor advocate (or some similar mechanism), and other ethical concerns. The American Academy of Pediatrics holds that minors can ethically serve as stem cell donors when specific criteria are fulfilled. Pediatrics 2010; 125:392-404

Short TitlePolicy Statement-Children as Hematopoietic Stem Cell Donors
Notify Library Reference ID442

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