01991nas a2200217   4500008003900000245006400039210006300103260000800166300001400174490000800188520140300196100001701599700001401616700002201630700001701652700001401669700001801683700001401701700001401715856004401729       2010                          d00aPolicy Statement-Children as Hematopoietic Stem Cell Donors0 aPolicy StatementChildren as Hematopoietic Stem Cell Donors  cFeb  a392 - 4040 v1253 aIn the past half-century, hematopoietic stem cell transplantation has become standard treatment for a variety of diseases in children and adults, including selected hematologic malignancies, immunodeficiencies, hemoglobinopathies, bone marrow failure syndromes, and congenital metabolic disorders. There are 3 sources of allogeneic hematopoietic stem cells: bone marrow, peripheral blood, and umbilical cord blood; each has its own benefits and risks. Children often serve as hematopoietic stem cell donors, most commonly for their siblings. HLA-matched biological siblings are generally preferred as donors because of reduced risks of transplant-related complications as compared with unrelated donors. This statement includes a discussion of the ethical considerations regarding minors serving as stem cell donors, using the traditional benefit/burden calculation from the perspectives of both the donor and the recipient. The statement also includes an examination of the circumstances under which a minor may ethically participate as a hematopoietic stem cell donor, how the risks can be minimized, what the informed-consent process should entail, the role for a donor advocate (or some similar mechanism), and other ethical concerns. The American Academy of Pediatrics holds that minors can ethically serve as stem cell donors when specific criteria are fulfilled. Pediatrics 2010; 125:392-4041 aDiekema, D S1 aFallat, M1 aAntommaria, A H M1 aHolzman, I R1 aKatz, A L1 aLeuthner, S R1 aRoss, L F1 aWebb, S A  uhttps://notifylibrary.org/reference/442