Passive donor-to-recipient transfer of antiphospholipid syndrome following allogeneic stem-cell transplantation.

TitlePassive donor-to-recipient transfer of antiphospholipid syndrome following allogeneic stem-cell transplantation.
Publication TypeJournal Article
Year of Publication2005
AuthorsRitchie DS, Sainani A, D'Souza A, Grigg AP
JournalAmerican journal of hematology//Am J Hematol
Volume79
Issue4
Pagination299 - 302
Date Published2005
ISBN Number0361-8609
Other Numbers3h4, 7610369
Keywords*Antiphospholipid Syndrome/et [Etiology], *Bone Marrow Transplantation, *Graft vs Host Disease/im [Immunology], *Leukemia, Myelogenous, Chronic, BCR-ABL Positive/th [Therapy], Adult, Antiphospholipid Syndrome/im [Immunology], Autoantibodies/an [Analysis], Autoantibodies/im [Immunology], B-Lymphocytes/im [Immunology], Bone Marrow Transplantation/im [Immunology], Humans, Immunologic Memory, Lymphocyte Activation/im [Immunology], Male, Tissue Donors, Transplantation, Homologous
Abstract

Autoantibody production following allogeneic stem-cell transplantation is common and is often ascribed to the immune dysregulation associated with graft-versus-host disease. Recent data suggests that donor-memory B cells can be reactivated on exposure to antigen and result in antibody production in the recipient identical to that seen in the donor. Here we describe the production of autoantibodies in a recipient of bone marrow from a donor with systemic lupus erythematosus and antiphospholipid syndrome. Autoantibody appearance was precipitated by the onset of graft-versus-host disease, was identical to that of the donor, and ultimately lead to cerebrovascular thrombosis, which was successfully treated with antiplatelet and anticoagulant therapy.Copyright (c) 2005 Wiley-Liss, Inc.
Notify Library Reference ID4363

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