What is the true significance of donor-related cytomegalovirus transmission in the setting of facial composite tissue allotransplantation?.

TitleWhat is the true significance of donor-related cytomegalovirus transmission in the setting of facial composite tissue allotransplantation?.
Publication TypeJournal Article
Year of Publication2011
AuthorsGordon CR, Abouhassan W, Avery RK
JournalTransplantation proceedings//Transplant Proc
Volume43
Issue9
Pagination3516 - 20
Date Published2011
ISBN Number1873-2623
Other Numberswe9, 0243532
Keywords*Cytomegalovirus Infections/tm [Transmission], *Facial Transplantation/ae [Adverse Effects], Antiviral Agents/pd [Pharmacology], Cytomegalovirus/me [Metabolism], Humans, Opportunistic Infections/tm [Transmission], Organ Transplantation/ae [Adverse Effects], Postoperative Complications, risk, Tissue Donors, Transplantation, Homologous
Abstract

Face transplantation (FT) is fraught with complications parallel to solid organ transplantation (SOT). As such, donor-related cytomegalovirus (CMV) transmission remains one of the most commonly feared viruses associated with FT. With this in mind, a review of the literature seemed justified, knowing that two of the first four face transplant recipients acquired CMV donor-related viral infection. Although the risk of CMV transmission is acceptable in the setting of SOT, the scenario for those composite tissue allotransplantation (CTA) patients, who are often young and healthy, may be different. Experiences from France and Cleveland have both confirmed suboptimal events related to CMV transmission following transplantation. Therefore, using the information provided here, it is imperative that all FT teams remain aware of these potential risks. Furthermore, all patients pursuing facial CTA should be fully informed as to the risks of donor-related CMV transmission, understand the importance of prophylaxis, and be aware of alternative therapies required to prevent symptomatic disease.Copyright © 2011. Published by Elsevier Inc.

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