Cytomegalovirus (CMV)

Status: 
Ready to upload
Record number: 
1389
Adverse Occurrence type: 
Cytomegalovirus (CMV)
MPHO Type: 
Face
Estimated frequency: 
Currently there are two case reports summarizing CMV transmission, infection, and/or related complications pertaining to face transplantation (2011)
Time to detection: 
N/A
Alerting signals, symptoms, evidence of occurrence: 
Recurrent CMV viremia complicated by ganciclovir/valganciclovir induced neutropenia.
Demonstration of imputability or root cause: 
Seronegative recipient receiving face transplant from a seropositive donor (CMV D+/R-)
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Infections -- Viral
Infections
Keywords: 
CMV (cytomegalovirus)
face
composite tissue
transplantation
viremia
neutropenia
mismatch
serology
prophylaxis
preemptive treatment
References: 
What is the true significance of donor-related cytomegalovirus transmission in the setting of facial composite tissue allotransplantation?.
Reference attachment: 
PDF icon _ _ CMV, Gordon, 2011.pdf
Suggest references: 
Gordon CR, Abouhassan W, Avery RK.What Is The True Significance of Donor-Related Cytomegalovirus Transmission in the Setting of Facial Composite Tissue Allotransplantation? Transplant Proc. 2011 Nov;43(9):3516-20
Note: 
New voice in the MPHO taxonomy: Organs/Composite tissues grafts/Face (Evi) ------------------------------------------------------------------------------------------------------------- Agree with adding face transplant to the overall organ transplant taxonomy. This paper summarizes two case reports that were not necessarily unexpected transmissions of CMV, D+/R- (despite prophylaxis) and the risk for CMV transmission is not new information in SOT. While the development despite prophylaxis and the possible need for future prolonged prophylaxis in FT recipients is suggested in this paper, the authors also state that with two cases one cannot summarize. While this bears further evaluation for the future should facial transplants become more common, I suggest that rather than have a separate listing for this paper, we add the paper to the library, and add the facial transplant to the general list of organs for which CMV is transmitted---as in consolidate this information with other case reports of CMV in SOT in D+/R- cases despite prophylaxis. Same for Lung separate from SOT. Recommend we consolidate all under SOT. ------------------------------------------- Since there are different MPHOs involved it is necessary to create separate records (Evi)
Expert comments for publication: 
This paper summarizes two case reports that were not necessarily unexpected transmissions of CMV, D+/R- (despite prophylaxis) and the risk for CMV transmission is not new information in solid organ transplantation. While the development despite prophylaxis and the possible need for future prolonged prophylaxis in face transplantation recipients is suggested in this paper, the authors also state that with two cases one cannot summarize.