Title | The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Vlaar AP, Hofstra JJ, Determann RM, Veelo DP, Paulus F, Kulik W, Korevaar J, de Mol BA, Koopman MM, Porcelijn L, Binnekade JM, Vroom MB, Schultz MJ, Juffermans NP |
Journal | Blood//Blood |
Volume | 117 |
Issue | 16 |
Pagination | 4218 - 25 |
Date Published | 2011 |
ISBN Number | 1528-0020 |
Other Numbers | a8g, 7603509 |
Keywords | *Acute Lung Injury/ep [Epidemiology], *Blood Transfusion/ae [Adverse Effects], *Cardiac Surgical Procedures/ae [Adverse Effects], Acute Lung Injury/th [Therapy], Aged, Aged, 80 and over, Case-Control Studies, Female, Humans, Incidence, Male, Middle Aged, Prospective Studies, Risk Factors, Treatment Outcome |
Abstract | Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related morbidity and mortality. Both antibodies and bioactive lipids that have accumulated during storage of blood have been implicated in TRALI pathogenesis. In a single-center, nested, case-control study, patients were prospectively observed for onset of TRALI according to the consensus definition. Of 668 patients, 16 patients (2.4%) developed TRALI. Patient-related risk factors for onset of TRALI were age and time on the cardiopulmonary bypass. Transfusion-related risk factors were total amount of blood products (odds ratio [OR] = 1.2; 95% confidence interval [CI], 1.03-1.44), number of red blood cells stored more than 14 days (OR = 1.6; 95% CI, 1.04-2.37), total amount of plasma (OR = 1.2; 95% CI, 1.03-1.44), presence of antibodies in donor plasma (OR = 8.8; 95% CI, 1.8-44), and total amount of transfused bioactive lipids (OR = 1.0; 95% CI, 1.00-1.07). When adjusted for patient risk factors, only the presence of antibodies in the associated blood products remained a risk factor for TRALI (OR = 14.2; 95% CI, 1.5-132). In-hospital mortality of TRALI was 13% compared with 0% and 3% in transfused and nontransfused patients, respectively (P |
Notify Library Reference ID | 4167 |
The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study.
Related Incidents
- 1070 - TRALI (Transfusion Related Acute Lung Injury) - Plasma