Record number:
1070
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
1000 consecutive cardiac sugery patients.TRALI patients matched 1:2 with controls (transfused patients not developing ALI or non-transfused patients.2.4% developed possible TRALI. TRALI associated with older age patients and higher EUROscore and ASA scores, and longer clamp, pump, and surgery time. TRALI patients received more RBC, FFP, and PLTS. Median storage time of RBC's not different between groups. TRALI patients received more products with anti-HLA Class I and II antibodies. In hospital mortality for patients developing TRALI was 13% compared to 0% and 3% in transfused and non-transfused patients.
Time to detection:
<6 hours
Alerting signals, symptoms, evidence of occurrence:
New onset hypoxemia or arterial O2/fraction inspired O2<300mmHg, bilateral pulmonary changes, LAP<18mmHg
Demonstration of imputability or root cause:
Consensus Conference criteria used
Keywords:
Suggest references:
Vlaar, A.P., Hofstra, J.J.,Dtermann, R.M., Veelo, D.P., Paulus, F., Kulik, W., Korevaar, J., et.al. The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study. Blood 2011: 117(16): 4218-25.