Chagas' disease and kidney donation.

TitleChagas' disease and kidney donation.
Publication TypeJournal Article
Year of Publication2013
AuthorsMarquez E, Crespo M, Mir M, Perez-Saez MJ, Quintana S, Barbosa F, Pascual J
JournalNefrologia : publicacion oficial de la Sociedad Espanola Nefrologia//Nefrologia
Pagination128 - 33
Date Published2013
ISBN Number1989-2284
Other Numbersdlp, 8301215
Keywords*Chagas Disease, *Donor Selection/st [Standards], *Kidney Transplantation, Adult, Antibodies, Protozoan, Chagas Disease/bl [Blood], Female, Humans, Male, Middle Aged, Trypanosoma cruzi/im [Immunology]

Due to current trends in human population movements, there has been an increase in the number of individuals with Chagas’ disease (CD) living in non-endemic regions; as such, there is a high probability that we will face an increase in cases of CD, both in patients requiring renal replacement therapy and in potential donors. We present the case of an organ donor with positive serology for Trypanosoma cruzi, whose kidneys were implanted into two different recipients. Prophylaxis was administered with benznidazole for 3 weeks. Over the course of two years of serological and clinical follow-up, no evidence of Chagas’ transmission or infection was observed. This positive evolution suggests that renal transplants derived from donors with positive serology results and no signs of acute or chronic disease may be acceptable. We also provide a review of the evidence supporting this conclusion and the available recommendations in the medical literature.

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