Trypanosoma cruzi

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Transmission rates without recipient chemoprophylaxis is in the order of 18 to 22% according to different cases series.
Time to detection: 
Alerting signals, symptoms, evidence of occurrence: 
FIRST CASE: living donor known positive by ELISA and negative by PCR, treated with 5-nitrofurazone prior to donation. Recipient case 1 received prophylactic treatment to avoid infection and never seroconverted after 6 years of follow-up. Recipient case 2: living donor known positive by ELISA and PCR. 5-nitrofurazone was provided to recipient prohpylacticaly for one month prior to transplant through to 2 months after transplant. PCR negative at 7 months post-transplant. SECOND CASE: organ donor with positive serology for Trypanosoma cruzi, whose kidneys were implanted into two different recipients. Prophylaxis was administered with benznidazole for 3 weeks. Over the course of two years of serological and clinical follow-up, no evidence of Chagas' transmission or infection was observed.
Demonstration of imputability or root cause: 
Intervention without documented transmission (IWDT). Recipients of known positive donors received therapy with 5-nitrofurazone. No evidence of transmission.
Reference attachment: 
Suggest references: 
Ortiz AM; Troncoso P; Sainz M; and Vilches S. Prophylaxis and Treatment of Chagas Disease in Renal Transplant Donor and Recipient: Case Report. Transplantation Proceedings; 42: 393-4.