Scratching the surface of allergic transfusion reactions.

TitleScratching the surface of allergic transfusion reactions.
Publication TypeJournal Article
Year of Publication2013
AuthorsSavage WJ, Tobian AA, Savage JH, Wood RA, Schroeder JT, Ness PM
Pagination1361 - 71
Date Published2013
ISBN Number1537-2995
Other Numberswdn, 0417360
Keywords*Blood Group Incompatibility/im [Immunology], *Blood Platelets/im [Immunology], *Blood Proteins/im [Immunology], *Hypersensitivity/im [Immunology], Blood Transfusion/ae [Adverse Effects], Humans, Platelet Transfusion/ae [Adverse Effects]

Allergic transfusion reactions (ATRs) are a spectrum of hypersensitivity reactions that are the most common adverse reaction to platelets and plasma, occurring in up to 2% of transfusions. Despite the ubiquity of these reactions, little is known about their mechanism. In a small subset of severe reactions, specific antibody has been implicated as causal, although this mechanism does not explain all ATRs. Evidence suggests that donor, product, and recipient factors are involved, and it is possible that many ATRs are multifactorial. Further understanding of the mechanisms of ATRs is necessary so that rationally designed and cost-effective prevention measures can be developed.Copyright © 2012 American Association of Blood Banks.

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