Transmission of syphilis by solid organ transplantation.

TitleTransmission of syphilis by solid organ transplantation.
Publication TypeJournal Article
Year of Publication2006
AuthorsCortes NJ, Afzali B, MacLean D, Goldsmith DJ, O'Sullivan H, Bingham J, Lewis DA, MacMahon E, Tong CY, Koffman G
JournalAm J Transplant
Pagination2497 - 9
Date PublishedOct
Accession Number16827785
KeywordsAdult, Antibodies, Bacterial, Female, Follow-Up Studies, Humans, Kidney Transplantation, Male, Syphilis, Treponema pallidum

Two organ recipients developed serologic evidence of syphilis infection after renal transplantation from a common deceased donor with a history of treated syphilis. Testing of donor serum for syphilis, which occurred after transplantation, gave results interpreted as consistent with past infection. However, subsequent serologic results in the recipients suggested transmission of infection at transplantation due to active infection of the donor. This may be explained by recent donor re-infection in view of the current syphilis epidemic in the United Kingdom. An initial error in the treatment of recipients further served to highlight unfamiliarity in managing this resurgent infection in the context of organ transplantation.

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