Transmission of cancer with cadaveric donor organs

TitleTransmission of cancer with cadaveric donor organs
Publication TypeJournal Article
Year of Publication1995
AuthorsConlon PJ, Smith SR
JournalJ Am Soc Nephrol
Pagination54 - 60
Date PublishedJul
Accession Number7579070
KeywordsAdult, Cadaver, Carcinoma, Non-Small-Cell Lung / pathology / secondary, Female, Humans, Immunosuppression / adverse effects, Kidney Neoplasms / *secondary / surgery, Kidney Transplantation / *adverse effects, Lung Neoplasms / pathology, Male, Middle Aged, Nephrectomy, Reoperation, Tissue Donors

A case is presented in which each of the recipients of a pair of cadaveric kidneys developed metastatic carcinoma. One of the recipients died, and the other demonstrated involution of metastatic deposits after graft nephrectomy and withdrawal of immunosuppression. By the use of polymerase chain reaction of minisatellite regions of donor and recipient DNA, the donor origin of the tumor was conclusively demonstrated. Although a relatively uncommon complication of cadaveric renal transplantation, the transmission of cancer with cadaveric organs may become more frequent as older donors are accepted for organ donation.

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