Case Report: Carcinoma of Unknown Type (suspect lung) (1995)

Record number:

Adverse Occurrence type:

MPHO Type:

Estimated frequency:

The tumor is technically of unknown primary site, but the suspicion is that it is of donor pulmonary origin. Most recent risk assessment for Lung Cancer (Council of Europe, 2022): Any histotype of newly-diagnosed lung cancer is an unacceptable risk for organ donation. Lung cancer in the donor history: Treated lung cancer is considered to be associated with a high transmission risk. Risk may decrease after curative therapy, with recurrence-free time and with increasing probability of cure.

Time to detection:

11 months

Alerting signals, symptoms, evidence of occurrence:

Recipient 1: Dyspnea, transbronchial biopsy revealing poorly differentiated non-small cell carcinoma. CT showed nodular lung lesions and enlargement of the kidney allograft. Nephrectomy performed and biopsy showed a poorly differentiated carcinoma. No evidence of tumor recurrence 6 months after nephrectomy. Recipient 2: Graft nephrectomy performed because of deterioration of renal function. Graft showed malignant cells.

Demonstration of imputability or root cause:

Both kidneys from the same donor affected. Karyotype analysis was performed in one case, which showed donor-recipient gender mismatch and DNA fingerprinting was performed in the second case which confirmed donor origin.

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Keywords:

non small cell carcinoma

nodular

lung