Circulatory arrest during PBPC apheresis in an unrelated donor

TitleCirculatory arrest during PBPC apheresis in an unrelated donor
Publication TypeJournal Article
Year of Publication2003
AuthorsCassens U, Baumann C, Hillmann H, Reinecke H, Silling G, Booke M, Wawer A, Sibrowski W
Pagination736 - 41
Keywords*Blood Component Removal / ae [Adverse Effects], *Heart Arrest / et [Etiology], *Hematopoietic Stem Cell Transplantation, *Hematopoietic Stem Cells / cy [Cytology], Adult, Female, Graft vs Host Disease / pc [Prevention & Control], Granulocyte Colony-Stimulating Factor / ae [Adverse Effects], Humans

BACKGROUND: Nowadays, the collection of PBPCs by apheresis from healthy donors is a routine method. The mobilization with rHu G-CSF and the apheresis procedures are usually well tolerated without severe side effects. STUDY DESIGN AND METHODS: We report a severe complication in a 41-year-old unrelated female donor who was allowed to donate PBPCs and was mobilized with 10 microg of G-CSF per kg per day. During PBPC apheresis, she experienced a circulatory arrest after 132 minutes and processing of 7078 mL of blood (twice the donor's blood volume). RESULTS: Immediate cardiopulmonary resuscitation restored sinus rhythm and regulatory respiration without sequelae. Subsequent cardiologic examinations (heart catheterization, electrophysiologic testing, tilting table test) resulted in the diagnosis of a neurocardiogenic syncope. Other cardiac or circulatory disorders could be excluded. The implantation of a cardiac pacemaker was recommended to the donor. The 4-year-old recipient was successfully transplanted with the partial product collected until the arrest occurred. The patient received a total of 2.54 x 106 CD34+ cells per kg of body weight. CONCLUSION: After exclusion of other cardiac diseases, the diagnosed neurocardiogenic syncope probably induced the circulatory arrest during apheresis rather than the administration of G-CSF.

Short TitleCirculatory arrest during PBPC apheresis in an unrelated donor
Notify Library Reference ID306

Related Incidents