@article {306,
	title = {Circulatory arrest during PBPC apheresis in an unrelated donor},
	journal = {Transfusion},
	volume = {43},
	year = {2003},
	note = {HPC},
	pages = {736 - 41},
	abstract = {BACKGROUND: Nowadays, the collection of PBPCs by apheresis from healthy donors is a routine method. The mobilization with rHu G-CSF and the apheresis procedures are usually well tolerated without severe side effects. STUDY DESIGN AND METHODS: We report a severe complication in a 41-year-old unrelated female donor who was allowed to donate PBPCs and was mobilized with 10 microg of G-CSF per kg per day. During PBPC apheresis, she experienced a circulatory arrest after 132 minutes and processing of 7078 mL of blood (twice the donor{\textquoteright}s blood volume). RESULTS: Immediate cardiopulmonary resuscitation restored sinus rhythm and regulatory respiration without sequelae. Subsequent cardiologic examinations (heart catheterization, electrophysiologic testing, tilting table test) resulted in the diagnosis of a neurocardiogenic syncope. Other cardiac or circulatory disorders could be excluded. The implantation of a cardiac pacemaker was recommended to the donor. The 4-year-old recipient was successfully transplanted with the partial product collected until the arrest occurred. The patient received a total of 2.54 x 106 CD34+ cells per kg of body weight. CONCLUSION: After exclusion of other cardiac diseases, the diagnosed neurocardiogenic syncope probably induced the circulatory arrest during apheresis rather than the administration of G-CSF.},
	keywords = {*Blood Component Removal / ae [Adverse Effects], *Heart Arrest / et [Etiology], *Hematopoietic Stem Cell Transplantation, *Hematopoietic Stem Cells / cy [Cytology], Adult, Female, Graft vs Host Disease / pc [Prevention \& Control], Granulocyte Colony-Stimulating Factor / ae [Adverse Effects], Humans},
	author = {Cassens,U. and Baumann,C. and Hillmann,H. and Reinecke,H. and Silling,G. and Booke,M. and Wawer,A. and Sibrowski,W.}
}
