Mobilizing stem cells from normal donors: is it possible to improve upon G-CSF?

TitleMobilizing stem cells from normal donors: is it possible to improve upon G-CSF?
Publication TypeJournal Article
Year of Publication2007
AuthorsCashen AF, Lazarus HM, Devine SM
JournalBone Marrow Transplantation
Pagination577 - 88
Date PublishedMay
Type of ArticleReview
ISSN0268-3369 (Print) 0268-3369 (Linking)
Accession Number17369869
KeywordsBone Marrow Transplantation, effects / *pharmacology, effects / pharmacology, Granulocyte Colony Stimulating Factor, Recombinant / adverse, Granulocyte Macrophage Colony-Stimulating Factors, Recombinant / adverse, Hematopoietic Stem Cell Mobilization / adverse effects / *methods, Hematopoietic Stem Cells / cytology / drug effects / metabolism, Heterocyclic Compounds / adverse effects / pharmacology, Humans, Safety, Tissue Donors, Transplantation, Homologous

Currently, granulocyte colony stimulating factor (G-CSF) remains the standard mobilizing agent for peripheral blood stem cell (PBSC) donors, allowing the safe collection of adequate PBSCs from the vast majority of donors. However, G-CSF mobilization can be associated with some significant side effects and requires a multi-day dosing regimen. The other cytokine approved for stem cell mobilization, granulocyte-macrophage colony stimulating factor (GM-CSF), alters graft composition and may reduce the development of graft-versus-host disease, but a significant minority of donors fails to provide sufficient CD34+ cells with GM-CSF and some experience unacceptable toxicity. AMD3100 is a promising new mobilizing agent, which may have several advantages over G-CSF for donor mobilization. As it is a direct antagonist of the interaction between the chemokine stromal-derived factor-1 and its receptor CXCR4, AMD3100 mobilizes PBSCs within hours rather than days. It is also well tolerated, with no significant side effects reported in any of the clinical trials to date. Studies of autologous and allogeneic transplantation of AMD3100 mobilized grafts have demonstrated prompt and stable engraftment. Here, we review the current state of stem cell mobilization in normal donors and discuss novel strategies for donor stem cell mobilization.

Alternate JournalBone Marrow Transplant
Notify Library Reference ID301

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