| Title | Microbial contamination of hematopoietic progenitor cell products: clinical outcome |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Patah PA, Parmar S, McMannis J, Sadeghi T, Karandish S, Rondon G, Tarrand J, Champlin R, de Lima M, Shpall EJ |
| Volume | 40 |
| Issue | 4 |
| Pagination | 5 |
| Date Published | Aug |
| ISSN | 0268-3369; 0268-3369 |
| Accession Number | PMID: 17572714; 1705731 [pii] |
| Keywords | Antibiotic Prophylaxis / methods, Bacteremia / prevention & control, Blood Component Removal / methods, Cross Infection / microbiology / prevention & control, Hematopoietic Stem Cell Transplantation / adverse effects, Hematopoietic Stem Cells / microbiology, Humans, Medical Audit, Retrospective Studies, Texas, Transplantation, Autologous, Transplantation, Homologous |
| Abstract | We reviewed the results of routine microbiological assays of 3078 infused hematopoietic progenitor cell (HPC) products for autologous and allogeneic transplantation between January 2001 and December 2005. Thirty-seven (1.2%) contaminated products were found. All patients receiving contaminated infusions received empirical antibiotic prophylaxis according to the assay result. None of these patients developed a positive blood culture with the same agent, developed infections that could be attributable to the contaminated product or experienced any clinical sequelae. Coagulase-negative Staphylococcus was found in 32 (86.5%) products. Admission lengths and time to engraftment were within the expected time frame for autologous and allogeneic transplants. Microbial contamination of HPC products occurs at a low frequency; prophylactic use of antibiotics based on the microbiological assay appears to be effective in preventing clinical complications. |
| DOI | 10.1038/sj.bmt.1705731 |
| Alternate Journal | Bone Marrow Transplant. |
| Notify Library Reference ID | 1778 |
