Solid organ transplant-associated lymphocytic choriomeningitis, United States, 2011

TitleSolid organ transplant-associated lymphocytic choriomeningitis, United States, 2011
Publication TypeJournal Article
Year of Publication2012
AuthorsMacneil A, Stroher U, Farnon E, Campbell S, Cannon D, Paddock CD, Drew CP, Kuehnert M, Knust B, Gruenenfelder R, Zaki SR, Rollin PE, Nichol ST, Team LC
Date PublishedAug
ISSN1080-6059; 1080-6040
Accession NumberPMID: 22839997

Three clusters of organ transplant-associated lymphocytic choriomeningitis virus (LCMV) transmissions have been identified in the United States; 9 of 10 recipients died. In February 2011, we identified a fourth cluster of organ transplant-associated LCMV infections. Diabetic ketoacidosis developed in the organ donor in December 2010; she died with generalized brain edema after a short hospitalization. Both kidneys, liver, and lung were transplanted to 4 recipients; in all 4, severe posttransplant illness developed; 2 recipients died. Through multiple diagnostic methods, we identified LCMV infection in all persons, including in at least 1 sample from the donor and 4 recipients by reverse transcription PCR, and sequences of a 396-bp fragment of the large segment of the virus from all 5 persons were identical. In this cluster, all recipients developed severe illness, but 2 survived. LCMV infection should be considered as a possible cause of severe posttransplant illness.

DOI10.3201/eid1808.120212; 10.3201/eid1808.120212
Alternate JournalEmerg.Infect.Dis.
Notify Library Reference ID1757

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