TY - JOUR T1 - Solid organ transplant-associated lymphocytic choriomeningitis, United States, 2011 Y1 - 2012 A1 - Macneil,A. A1 - Stroher,U. A1 - Farnon,E. A1 - Campbell,S. A1 - Cannon,D. A1 - Paddock,C. D. A1 - Drew,C. P. A1 - Kuehnert,M. A1 - Knust,B. A1 - Gruenenfelder,R. A1 - Zaki,S. R. A1 - Rollin,P. E. A1 - Nichol,S. T. A1 - LCMV Transplant Investigation Team AB - Three clusters of organ transplant-associated lymphocytic choriomeningitis virus (LCMV) transmissions have been identified in the United States; 9 of 10 recipients died. In February 2011, we identified a fourth cluster of organ transplant-associated LCMV infections. Diabetic ketoacidosis developed in the organ donor in December 2010; she died with generalized brain edema after a short hospitalization. Both kidneys, liver, and lung were transplanted to 4 recipients; in all 4, severe posttransplant illness developed; 2 recipients died. Through multiple diagnostic methods, we identified LCMV infection in all persons, including in at least 1 sample from the donor and 4 recipients by reverse transcription PCR, and sequences of a 396-bp fragment of the large segment of the virus from all 5 persons were identical. In this cluster, all recipients developed severe illness, but 2 survived. LCMV infection should be considered as a possible cause of severe posttransplant illness. CY - United States VL - 18 CP - 8 N1 - JID: 9508155; OID: NLM: PMC3414043; ppublish L2 - Journal Article; Research Support, U.S. Gov't, P.H.S.; IM ID - 1757 ER -