The incidence and importance of bacterial contaminants of cadaveric renal perfusion fluid

TitleThe incidence and importance of bacterial contaminants of cadaveric renal perfusion fluid
Publication TypeJournal Article
Year of Publication2005
AuthorsWakelin SJ, Casey J, Robertson A, Friend P, Jaques BC, Yorke H, Rigden SP, Emmanuel XF, Pareja-Cebrian L, Forsythe JL, Morris PJ
JournalTransplant international : official journal of the European Society for Organ Transplantation
Pagination680 - 6
Date PublishedJan
Type of ArticleMulticenter Study
ISSN0934-0874 (Print) 0934-0874 (Linking)
Accession Number15565355
Keywords*Drug Contamination, *Kidney, *Kidney Transplantation, *Organ Preservation Solutions, *Perfusion, Antibiotic Prophylaxis, Bacteria / *isolation & purification, Blood / microbiology, Cadaver, Humans, Peritoneum / microbiology, Preoperative Care, Tissue and Organ Procurement, Tissue Donors

Infections represent a significant risk in the postoperative transplant recipient. The perfusion fluid used to perfuse and preserve the kidneys prior to transplantation represents a potential medium in which organisms can grow. The aim of this study was to determine the incidence and clinical relevance of bacterial contamination of perfusion fluid. A total of 4 centres participated in the study and 269 perfusion fluid samples were taken for microbiological analysis. Organisms were isolated from 38 out of 218 (17.4%) perfusion fluid samples taken prior to allograft implantation and 23 out of 51 (45%) samples taken at procurement. Low virulence organisms predominated although Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli were also isolated. Although infective complications were not seen in the allograft recipients, given the frequency with which contamination occurs and the variation in unit antibiotic protocols, we recommend the routine culturing of perfusion fluid to ensure that any potentially significant organisms are identified and treated appropriately.

Alternate JournalTranspl Int
Notify Library Reference ID1598

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