Transmission of thyrotoxicosis of autoimmune type by sibling allogeneic bone marrow transplant

TitleTransmission of thyrotoxicosis of autoimmune type by sibling allogeneic bone marrow transplant
Publication TypeJournal Article
Year of Publication1995
AuthorsThomson JA, Wilson RM, Franklin IM
JournalEur J Endocrinol
Volume133
Issue5
Pagination564 - 6
Date PublishedNov
ISSN0804-4643 (Print) 0804-4643 (Linking)
Accession Number7581986
KeywordsAdult, Autoantibodies / metabolism, Autoimmune Diseases / *etiology / *genetics / immunology, Bone Marrow Transplantation / *adverse effects / immunology, Family Health, Female, Humans, Karyotyping, Leukemia, Myeloid, Acute / genetics / therapy, Lymphocytes / metabolism, Male, Radioimmunoassay, Thyroiditis, Autoimmune / genetics / immunology, Thyrotoxicosis / *etiology / *genetics / immunology, Transplantation, Homologous
Abstract

This case report is on a 25-year-old male with acute myeloblastic leukaemia who achieved a remission after cytoxic therapy and whole-body irradiation. He received a bone marrow transplant from his human leucocyte antigen (HLA)-identical sister who had unsuspected autoimmune thyroid disease. Nine months later the bone marrow recipient developed thyrotoxicosis of autoimmune type at a time when his circulating lymphocytes were of 46XX karyotype. It is suspected that the thyrotoxicosis resulted from the transplantation of a clone of lymphocytes predisposed to the production of thyroid-stimulating autoantibodies.
Notify Library Reference ID1538

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