TY - JOUR T1 - Transmission of thyrotoxicosis of autoimmune type by sibling allogeneic bone marrow transplant JF - Eur J Endocrinol Y1 - 1995 A1 - Thomson,J. A. A1 - Wilson,R. M. A1 - Franklin,I. M. KW - Adult KW - Autoantibodies / metabolism KW - Autoimmune Diseases / *etiology / *genetics / immunology KW - Bone Marrow Transplantation / *adverse effects / immunology KW - Family Health KW - Female KW - Humans KW - Karyotyping KW - Leukemia, Myeloid, Acute / genetics / therapy KW - Lymphocytes / metabolism KW - Male KW - Radioimmunoassay KW - Thyroiditis, Autoimmune / genetics / immunology KW - Thyrotoxicosis / *etiology / *genetics / immunology KW - Transplantation, Homologous AB - This case report is on a 25-year-old male with acute myeloblastic leukaemia who achieved a remission after cytoxic therapy and whole-body irradiation. He received a bone marrow transplant from his human leucocyte antigen (HLA)-identical sister who had unsuspected autoimmune thyroid disease. Nine months later the bone marrow recipient developed thyrotoxicosis of autoimmune type at a time when his circulating lymphocytes were of 46XX karyotype. It is suspected that the thyrotoxicosis resulted from the transplantation of a clone of lymphocytes predisposed to the production of thyroid-stimulating autoantibodies. VL - 133 CP - 5 N1 - Thomson, J A Wilson, R M Franklin, I M Case Reports Norway European journal of endocrinology / European Federation of Endocrine Societies Eur J Endocrinol. 1995 Nov;133(5):564-6. ID - 1538 ER -