Fatal hemorrhage in two renal graft recipients with multi-drug resistant Pseudomonas aeruginosa infection

TitleFatal hemorrhage in two renal graft recipients with multi-drug resistant Pseudomonas aeruginosa infection
Publication TypeJournal Article
Year of Publication2009
AuthorsOrlando G, Di Cocco P, Gravante G, D'Angelo M, Famulari A, Pisani F
JournalTransplant infectious disease : an official journal of the Transplantation Society
Pagination442 - 7
Date PublishedOct
Type of ArticleCase Reports Research Support, Non-U.S. Gov't
ISSN1399-3062 (Electronic) 1398-2273 (Linking)
Accession Number19508700
Keywords*Drug Resistance, Multiple, Bacterial, Adult, Aneurysm, Ruptured, Anti-Bacterial Agents / pharmacology, Arteritis / *microbiology, Fatal Outcome, Female, Hemorrhage / *etiology, Humans, Iliac Artery / microbiology, Kidney Transplantation / *adverse effects, Male, Middle Aged, Pseudomonas aeruginosa / *drug effects / isolation & purification, Pseudomonas Infections / *complications / microbiology, Vertebral Artery / microbiology

Pseudomonas aeruginosa (PA) infections occurring after renal transplantation (RT) represent a potentially life-threatening complication. We present 2 cases of early death following RT in which PA was transmitted, possibly from the donor to the recipients, despite preoperative cultures that were negative. The donor had developed PA-related bilateral pneumonia while in the intensive care unit. However, after appropriate antibiotic therapy, no signs of infection were present at the time of organ retrieval and cultures were negative. Both recipients received a renal graft from the same donor and developed multi-drug resistant (MDR)-PA infections with bacterial phenotypes and resistances similar to the donor. The first recipient died 9 days after RT from rupture of a false aneurysm of the external iliac artery, caused by a fully thickened PA-related arteritis. The second recipient died postoperatively on day 10 after rupture of an aneurysm in the right vertebral artery. Our experience shows that MDR-PA infection early after RT may be a catastrophic event. Specific anti-PA antibiotic therapy in RT patients during the perioperative period is recommended in the case of PA infection in the donor, even after apparent successful therapy with negative cultures.

Alternate JournalTranspl Infect Dis
Notify Library Reference ID1108

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