TY - JOUR T1 - Fatal hemorrhage in two renal graft recipients with multi-drug resistant Pseudomonas aeruginosa infection JF - Transplant infectious disease : an official journal of the Transplantation Society Y1 - 2009 A1 - Orlando,G. A1 - Di Cocco,P. A1 - Gravante,G. A1 - D'Angelo,M. A1 - Famulari,A. A1 - Pisani,F. KW - *Drug Resistance, Multiple, Bacterial KW - Adult KW - Aneurysm, Ruptured KW - Anti-Bacterial Agents / pharmacology KW - Arteritis / *microbiology KW - Fatal Outcome KW - Female KW - Hemorrhage / *etiology KW - Humans KW - Iliac Artery / microbiology KW - Kidney Transplantation / *adverse effects KW - Male KW - Middle Aged KW - Pseudomonas aeruginosa / *drug effects / isolation & purification KW - Pseudomonas Infections / *complications / microbiology KW - Vertebral Artery / microbiology AB - Pseudomonas aeruginosa (PA) infections occurring after renal transplantation (RT) represent a potentially life-threatening complication. We present 2 cases of early death following RT in which PA was transmitted, possibly from the donor to the recipients, despite preoperative cultures that were negative. The donor had developed PA-related bilateral pneumonia while in the intensive care unit. However, after appropriate antibiotic therapy, no signs of infection were present at the time of organ retrieval and cultures were negative. Both recipients received a renal graft from the same donor and developed multi-drug resistant (MDR)-PA infections with bacterial phenotypes and resistances similar to the donor. The first recipient died 9 days after RT from rupture of a false aneurysm of the external iliac artery, caused by a fully thickened PA-related arteritis. The second recipient died postoperatively on day 10 after rupture of an aneurysm in the right vertebral artery. Our experience shows that MDR-PA infection early after RT may be a catastrophic event. Specific anti-PA antibiotic therapy in RT patients during the perioperative period is recommended in the case of PA infection in the donor, even after apparent successful therapy with negative cultures. VL - 11 CP - 5 N1 - Orlando, G ID - 1108 ER -