Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen. The National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database.

TitleTransmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen. The National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database.
Publication TypeJournal Article
Year of Publication1997
AuthorsDickson RC, Everhart JE, Lake JR, Wei Y, Seaberg EC, Wiesner RH, Zetterman RK, Pruett TL, Ishitani MB, Hoofnagle JH
JournalGastroenterology//Gastroenterology
Volume113
Issue5
Pagination1668 - 74
Date Published1997
ISBN Number0016-5085
Other Numbersfh3, 0374630
Keywords*Hepatitis B Antibodies/bl [Blood], *Hepatitis B Core Antigens/im [Immunology], *Hepatitis B/tm [Transmission], *Liver Transplantation/ae [Adverse Effects], *Tissue Donors, Hepatitis B Surface Antigens/im [Immunology], Humans
Abstract

BACKGROUND & AIMS: Organ donors are a potential source of transmissible disease after transplantation. The aim of this study was to evaluate the risk of acquiring hepatitis B among transplantation recipients of livers from donors without serum hepatitis B surface antigen (HBsAg) but with antibody to hepatitis B core antigen (anti-HBc)., METHODS: The transplantation experience of four centers between 1989 and 1994 was reviewed. Recipients of livers from 674 donors were considered informative for hepatitis B virus transmission., RESULTS: Hepatitis B developed in 18 of 23 recipients of livers from anti-HBc-positive donors (78%) compared with only 3 of 651 recipients of anti-HBc-negative donor livers (0.5%) (P

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