@article {4054,
	title = {Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen. The National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database.},
	journal = {Gastroenterology//Gastroenterology},
	volume = {113},
	year = {1997},
	month = {1997},
	pages = {1668 - 74},
	publisher = {Dickson,R C. University of Virginia Health Sciences Center, Charlottesville, USA.},
	address = {UNITED STATES},
	abstract = {BACKGROUND \& AIMS: Organ donors are a potential source of transmissible disease after transplantation. The aim of this study was to evaluate the risk of acquiring hepatitis B among transplantation recipients of livers from donors without serum hepatitis B surface antigen (HBsAg) but with antibody to hepatitis B core antigen (anti-HBc)., METHODS: The transplantation experience of four centers between 1989 and 1994 was reviewed. Recipients of livers from 674 donors were considered informative for hepatitis B virus transmission., RESULTS: Hepatitis B developed in 18 of 23 recipients of livers from anti-HBc-positive donors (78\%) compared with only 3 of 651 recipients of anti-HBc-negative donor livers (0.5\%) (P < 0.0001). HBsAg persisted in all recipients with donor-related hepatitis B. Liver histology showed chronic hepatitis of moderate severity in 2 of 13 recipients at 1 year and 5 of 8 recipients between 1.6 and 4.5 years from transplantation. Liver transplantation from an anti-HBc-positive donor was associated with decreased 4-year survival (adjusted mortality hazard ratio of 2.4; 95\% confidence interval, 1.4-4.0)., CONCLUSIONS: De novo posttransplantation hepatitis B infection occurs at a high rate in recipients of donors with anti-HBc. Transmission of hepatitis B through transplantation suggests that the virus may persist in the liver despite serological resolution of infection.},
	keywords = {*Hepatitis B Antibodies/bl [Blood], *Hepatitis B Core Antigens/im [Immunology], *Hepatitis B/tm [Transmission], *Liver Transplantation/ae [Adverse Effects], *Tissue Donors, Hepatitis B Surface Antigens/im [Immunology], Humans},
	isbn = {0016-5085},
	author = {Dickson, R C and Everhart, J E and Lake, J R and Wei, Y and Seaberg, E C and Wiesner, R H and Zetterman, R K and Pruett, T L and Ishitani, M B and Hoofnagle, J H}
}
