[Rabies transmission through organ transplantation]

Title	[Rabies transmission through organ transplantation]
Publication Type	Journal Article
Year of Publication	2011
Authors	Wohlsein P, Baumgartner W, Kreipe HH, Haverich A, Hori A, Stan AC
Volume	32
Issue	5
Pagination	6
Date Published	Sep
ISSN	0172-8113
Accession Number	21732080
Keywords	Adult, Brain / pa [Pathology], Eisenmenger Complex / su [Surgery], Encephalomyelitis / pa [Pathology], Female, Humans, IM, Immunohistochemistry, Inclusion Bodies, Viral / pa [Pathology], Lung Transplantation, Microscopy, Electron, Middle Aged, Neurons / pa [Pathology], Rabies / pa [Pathology], Rabies / tm [Transmission], Tissue Donors, Virion
Abstract	Classic rabies is a progressive and lethal infectious disease of animals, which may be transmitted to humans. Inter-human infections are extremely rare. The present case describes transmittal of rabies virus by lung transplantation from an infected donor. Histologically, a lymphocytic encephalomyelitis with neuronal cytoplasmic inclusion bodies was found. Immunohistochemically, rabies virus antigen was detected in the central, autonomous and peripheral nervous system. By means of electron microscopy, virions were demonstrated in the brain. A central task of health care in transplantations is the detection of uncommon infectious agents and the prevention of their transmittal.
DOI	10.1007/s00292-011-1452-0
Alternate Journal	Pathologe
Notify Library Reference ID	1836

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