Record number:
303
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment for leukemia, lymphoma and plasmacytoma (Council of Europe, 2022):
Leukaemia, lymphoma and plasmacytoma diagnosed during donor procurement: These cancers are classified as an unacceptable risk for organ donation. Leukaemia, lymphoma and plasmacytoma in the donor history: Active (acute or chronic) leukaemia, lymphoma and plasmacytoma are an unacceptable risk for organ donation. Treated acute leukaemia and lymphoma after a definite disease-free interval of 10 years may be considered for organ donation with an assumed high risk for transmission.
Time to detection:
18 months
Alerting signals, symptoms, evidence of occurrence:
monoclonal spike in serum
Demonstration of imputability or root cause:
HLA DNA typing of tumor and donor
Imputability grade:
1 Possible
Groups audience:
Suggest new keywords:
kidney transplant
malignancy
multiple myeloma
Reference attachment:
Suggest references:
AAA
Expert comments for publication:
It is not clear whether the myeloma that arose in the recipient 18 months after transplant was a posttransplant EBV-negative event, or represented malignancy transferred from the 67 year old donor at the time of transplant. No suspicion of neoplasia in the donor was present clinically at the time of transplant. No further donor related studies were possible.