Postrenal transplant non-EBV multiple myeloma of donor origin

TitlePostrenal transplant non-EBV multiple myeloma of donor origin
Publication TypeJournal Article
Year of Publication2006
AuthorsPeri N, Kussick S, Bakthavatsalam R, Mitsumori L, Dighe M
JournalAm J Transplant
Pagination419 - 22
Date PublishedFeb
Accession Number16426330
KeywordsAged, Bone Marrow / pathology, Chromosomes, Human, Y, Female, Herpesvirus 4, Human / isolation & purification, Humans, In Situ Hybridization, Fluorescence, Kidney Failure, Chronic / *surgery, Kidney Transplantation / *adverse effects / pathology, Multiple Myeloma / *etiology / genetics / pathology, Postoperative Complications / *diagnosis / pathology, Tissue Donors

Multiple myeloma occurring after solid organ transplantation is a rare condition, with only a few case reports found in the literature. We report a case of Epstein-Barr virus-negative, posttransplant multiple myeloma in a 67-year-old female, presenting 18 months after renal transplantation. Interestingly, fluorescence in situ hybridization analysis of the tumor revealed a Y chromosome in the majority of the cells, indicating that the neoplasm was derived from the donor kidney. To our knowledge, this represents the first reported case with these features.

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