Case report: Melanoma after liver transplant (1998)

Record number:

294

Adverse Occurrence type:

MPHO Type:

Estimated frequency:

Most recent risk assessment for melanoma (Council of Europe, 2022): Due to the very aggressive behaviour of this tumour, it is considered an unacceptable risk for organ donation. Malignant melanoma in the donor history: Due to the lack of exhaustive data, transplanting organs from donors with treated malignant melanoma must still be considered to be associated with a high transmission risk. If precise donor data about staging, therapy, follow-up and recurrence-free survival are available, and evaluation by the dermato-oncologist concludes there is a low probability of recurrence and metastasis, organ donation might be considered for selected recipients.

Time to detection:

9 months

Alerting signals, symptoms, evidence of occurrence:

Liver recipient assessed after notification of transmission in the two kidney recipients

Demonstration of imputability or root cause:

Donor with not known condition - Two kidney recipients and liver recipient affected. No envidence of transmission in the heart recipient. - Kidney recipient 1: Gene studies determined the origin of the tumor to be donor in type (tumour cells expressed HLA class 1 antigens mismatched in the recipient and mRNA for the costimulator B7, and the cytokines GM-CSF, IL-1 alpha and beta)

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Keywords: