Autosomal Dominant Cerebellar Ataxia (ADCA) transmission by donor sperm

Record number: 
101
Adverse Occurrence type: 
MPHO Type: 
Alerting signals, symptoms, evidence of occurrence: 
Sperm from a donor with ADCA was used for the conception of 18 children in 13 women. Half of the children would have inherited the gene but it would not have been detected in the offspring until after puberty. In this case, the donor himself was the first to manifest the condition.
Demonstration of imputability or root cause: 
The disease is unrelated to the woman receiving donor semen or to the partner of the woman using donor oocytes and the newborn is genetically related to the donor and the recipient
Imputability grade: 
3 Definite/Certain/Proven
Suggest references: 
aaa