| Title | Abnormal diffusion-weighted magnetic resonance imaging in Creutzfeldt-Jakob disease following corneal transplantations |
| Publication Type | Journal Article |
| Year of Publication | 2002 |
| Authors | Rabinstein AA, Whiteman ML, Shebert RT |
| Journal | Arch Neurol |
| Volume | 59 |
| Issue | 4 |
| Pagination | 637 - 9 |
| Date Published | Apr |
| ISSN | 0003-9942 (Print) 0003-9942 (Linking) |
| Accession Number | 11939901 |
| Keywords | *Corneal Transplantation, *Magnetic Resonance Imaging / methods, Brain / *pathology, Creutzfeldt-Jakob Syndrome / *diagnosis / pathology, Humans, Male, Middle Aged, Predictive Value of Tests |
| Abstract | BACKGROUND: The value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic cases of Creutzfeldt-Jakob disease has been questioned. OBJECTIVE: To illustrate the value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic Creutzfeldt-Jakob disease. METHODS: Case report. RESULTS: A patient with a history of 3 corneal transplantations exhibited the alien hand sign on initial examination. Diffusion-weighted magnetic resonance imaging of the brain revealed prominent cortical diffusion abnormalities. During the following months, the patient developed rapidly progressive dementia. The diagnosis of Creutzfeldt-Jakob disease was proven by brain biopsy. CONCLUSION: Brain magnetic resonance imaging, particularly diffusion-weighted magnetic resonance imaging, can be very helpful in the diagnosis of Creutzfeldt-Jakob disease, even in suspected iatrogenic cases. |
| URL | internal-pdf://Rabinstein - CJD-0541396993/Rabinstein - CJD.pdf |
| DOI | |
| Notify Library Reference ID | 1294 |
Abnormal diffusion-weighted magnetic resonance imaging in Creutzfeldt-Jakob disease following corneal transplantations
Related Incidents
- 410 - Creutzfeldt-Jacob disease (CJD) - Cornea