TY - JOUR T1 - Abnormal diffusion-weighted magnetic resonance imaging in Creutzfeldt-Jakob disease following corneal transplantations JF - Arch Neurol Y1 - 2002 A1 - Rabinstein,A. A. A1 - Whiteman,M. L. A1 - Shebert,R. T. KW - *Corneal Transplantation KW - *Magnetic Resonance Imaging / methods KW - Brain / *pathology KW - Creutzfeldt-Jakob Syndrome / *diagnosis / pathology KW - Humans KW - Male KW - Middle Aged KW - Predictive Value of Tests AB - BACKGROUND: The value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic cases of Creutzfeldt-Jakob disease has been questioned. OBJECTIVE: To illustrate the value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic Creutzfeldt-Jakob disease. METHODS: Case report. RESULTS: A patient with a history of 3 corneal transplantations exhibited the alien hand sign on initial examination. Diffusion-weighted magnetic resonance imaging of the brain revealed prominent cortical diffusion abnormalities. During the following months, the patient developed rapidly progressive dementia. The diagnosis of Creutzfeldt-Jakob disease was proven by brain biopsy. CONCLUSION: Brain magnetic resonance imaging, particularly diffusion-weighted magnetic resonance imaging, can be very helpful in the diagnosis of Creutzfeldt-Jakob disease, even in suspected iatrogenic cases. VL - 59 ER - internal-pdf://Rabinstein - CJD-0541396993/Rabinstein - CJD.pdf CP - 4 N1 - Rabinstein, Alejandro A Whiteman, Michelle L Shebert, Robert T Case Reports United States Archives of neurology Arch Neurol. 2002 Apr;59(4):637-9. ID - 1294 ER -