Recurrent seizure and sustained encephalopathy associated with dimethylsulfoxide-preserved stem cell infusion

TitleRecurrent seizure and sustained encephalopathy associated with dimethylsulfoxide-preserved stem cell infusion
Publication TypeJournal Article
Year of Publication2005
AuthorsBauwens D, Hantson P, Laterre PF, Michaux L, Latinne D, De Tourtchaninoff M, Cosnard G, Hernalsteen D
JournalLeukemia & lymphoma
Volume46
Issue11
Pagination1671 - 4
Date PublishedNov
Type of ArticleCase Reports
ISSN1042-8194 (Print) 1026-8022 (Linking)
Accession Number16236621
KeywordsCryopreservation / methods, Dimethyl Sulfoxide / *adverse effects, Fatal Outcome, Humans, Lymphoma, Large B-Cell, Diffuse / complications / therapy, Male, Neurotoxicity Syndromes / *etiology, Peripheral Blood Stem Cell Transplantation / *adverse effects, Recurrence, Seizures / *chemically induced, Tissue Preservation / methods
Abstract

We report the case of a patient who received two infusions of dimethylsulfoxide (DMSO) cryopreserved autologous peripheral blood progenitor cells (PBPCs) after myeloablative chemotherapy for a relapsing lymphoma. A 49-year-old man presented an episode of tonic-clonic seizure over a few minutes after the start of each infusion and developed a profound and sustained but reversible encephalopathy with coma after the second infusion. The patient's neurological condition correlated well with the electrophysiological findings (electroencephalogram and multimodality evoked potentials) and, to a lesser extent, with the radiological abnormalities (magnetic resonance imaging). Severe but reversible neurological complications may occur with the infusion of PBPCs cryopreserved with DMSO.

DOI10.1080/10428190500235611
Alternate JournalLeuk Lymphoma
Notify Library Reference ID146

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