Histoplasma capsulatum

Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
10 months
Alerting signals, symptoms, evidence of occurrence: 
Presented with progressive shortness of breath, productive cough with green sputum, low-grade fever, and a drop in flow rates at 10 months after transplantation. Endobronchial biopsy revealed mucosal necrosis and yeast forms, morphologically consistent with Histoplasma capsulatum. CT scan of the chest revealed a 1.0 × 0.7 cm calcified left hilar lymph node at the bifurcation of LMB that did not extend into the airway.
Demonstration of imputability or root cause: 
The donor, also a resident of the northeast Ohio River Valley, was a healthy asymptomatic male without any evidence of histoplasmosis. However, prior to the transplantation, a left lower lobe (LLL) wedge resection of the donor lung was performed for a <1-cm mass, the histopathology of which revealed a calcified necrotizing granuloma. Probable transmission.
Imputability grade: 
2 Probable
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