Case Report: Kaposi’s sarcoma after liver transplant (1996)

Record number: 
259
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Council of Europe recommendation for Kaposi sarcoma of skin and for sarcoma in general can be considered relevant and are as follows: Most recent risk assessment for non-melanoma skin cancer (Council of Europe, 2022): Basal cell and squamous cell carcinoma of the skin are considered minimal risk due to very rare metastases. Kaposi’s sarcoma, Merkel cell carcinoma and skin sarcoma are considered an unacceptable risk. Non-melanoma skin cancer in the donor history: Basal cell and squamous cell carcinoma of the skin are considered minimal risk due to very rare metastases. Kaposi’s sarcoma, Merkel cell carcinoma and skin sarcoma are considered an unacceptable risk. Most recent risk assessment for sarcoma (Council of Europe, 2022): Due to the very aggressive behavior of sarcoma, they are considered an unacceptable risk for organ donation at any stage of disease. Sarcoma in donor history: Because of the very aggressive behavior of sarcoma, they are mostly considered an unacceptable risk for organ donation. After curative treatment and a recurrence-free survival of > 5 years, sarcomas are still assumed to be associated with a high risk for transmission.
Time to detection: 
4 months
Alerting signals, symptoms, evidence of occurrence: 
About 130 days after tx, severe liver disfunction and patient´s death due to multiorgan failure. Liver graft biopsy at autopsy revealed a KS.
Demonstration of imputability or root cause: 
The anatomic distribution of the KS in the autopsy study, and the HLA haplotypes typed in the donor and in the recipient, suggested that the KS arose in the stromal endothelial cells of the donor liver.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
Case report
Liver transplant
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