Status:
Ready to upload
Record number:
2135
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
This is a systematic review of 62 manuscripts reporting on depression and anxiety in multiple types of living donation (kidney, n = 25; liver, n = 25; bone marrow, n = 7; uterus, n = 2; lung, n = 1; kidney and lung concurrently, n = 2). Post-transplantation depression and anxiety prevalence rates (Depression: 0–46.9%, Anxiety: 0–66.7%) did not differ significantly from pre-transplantation and were largely comparable to the general population.
Time to detection:
Ascertainment of anxiety and depression varied widely but most often included pre and post-operative time periods.
Alerting signals, symptoms, evidence of occurrence:
Evidence of occurrence was most often ascertained via donor self-report questionnaire/interview.
Demonstration of imputability or root cause:
Anxiety and depression rates did not change from pre to post-donation and were comparable to rates in the general population. Other psychological outcomes observed included lower quality of life, lower satisfaction of life and regret after donation. Pre-donation risk factors such as poor physical/psychological health status, and post-donation risk factors such as complicated post-surgical recovery and poor physical/psychological health in recipients were identified, predisposing donors to poor psychological outcomes.
Groups audience:
Suggest new keywords:
living donation, anxiety and depression, psychosocial issues
Reference attachment:
Suggest references:
Depression, anxiety, and associated psychological outcomes in living organ transplant donors: A systematic review. General Hospital Psychiatry 70 (2021) 51–75
Expert comments for publication:
The authors conclude that the prevalence of depression and anxiety in donors post-transplantation were largely comparable and may be lower than that of the general population. However, individuals with identifiable pre-donation and post-donation risk factors should be monitored and managed accordingly through methods such as provision of social support, psychoeducation, psychotherapy and long-term follow up.