Post PBSC donation clinical outcomes

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Time to detection: 
Several weeks or months following the donation.
Alerting signals, symptoms, evidence of occurrence: 
Typical of the cardio-vascular event (e.g. MI, TIA)
Imputability grade: 
1 Possible
Groups audience: 
Suggest references: 
Clinical outcomes after peripheral blood stem cell donation by related donors: a Dutch single-center cohort study. Wiersum-Osselton J.C. et al, TRANSFUSION 2013;53:96-103
Expert comments for publication: 
A direct association cannot be proven, however the finding that related donors with pre-donation cardio-vascular risk factors (e.g. hypertension) were significantly more likely to have post donation cardio-vascular events should be taken into consideration when selecting donors. It is unclear of the donation itself (GCSF, apheresis) accelerates any cardo-vascular events, or if the occurrence of these events simply reflects a population at greater risk irrespective of the donation.