KPC-producing Klebsiella pneumoniae

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Time to detection: 
5 days
Alerting signals, symptoms, evidence of occurrence: 
A 63-year-old liver recipient for HCV- related cirrhosis and hepatocarcinoma developed fever on day 5 post OLT. Klebsiella pneumoniae bacteraemia was confirmed from a central venous catheter derived blood culture. K. pneumoniae isolates with the same resistance profile were also obtained from subsequent blood cultures, surgical wound and abdominal drainage fluid. Patient was successfully treated with meropenem (1 g t.i.d.) plus gentamicin (240 mg once a day) for 5 days. Meropenem was then replaced with ertapenem (1 g once a day), and antibiotic treatment was prolonged for one more week.
Demonstration of imputability or root cause: 
The donor was a 52-year-old subject who died after cranial trauma and who (i) had a past history of pulmonary tuberculosis with negative results for acid-fast bacilli in respiratory secretions and no signs of active tuberculosis, (ii) had respiratory tract colonization with a carbapenem-resistant Acinetobacter (CRA). Blood and urine cultures, taken on the same day of organ explantation, were negative. Bacterial culture of the kidney preservation fluid had revealed K. pneumoniae with the same antibiotic resistance profile as the recipient's isolates, and the transplant centre had been informed of this finding. Characterisation of the isolates from the two recipients (kidney and liver) where identical by pulse-field gel electrophoresis (PFGE); multilocus sequencing typing (MLST) assigned all isolates to sequence type 16. OXA-48 producing K. pneumoniae were uncommon in Italy at the time of this event. The authors conclude that the donor was the most likely source but acknolwkedge the fact that this organism was not isolated from the donor.
Imputability grade: 
2 Probable
Suggest references: 
1) Cross-infection of solid organ transplant recipients by a multidrug-resistant Klebsiella pneumoniae isolate producing the OXA-48 carbapenemase, likely derived from a multiorgan donor. Giani T. et al. J Clin Microbiol. 52(7):2702-5, 2014 Jul. 2) C. Cervera, C. van Delden, J. Gavald, T. Welte, M. Akova, J. Carratal and on behalf of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH). Multidrug-resistant bacteria in solid organ transplant recipients. Clin Microbiol Infect. 2014 Sep;20 Suppl 7:49-73
Expert comments for publication: 
It has been suggested that organs from donors with KPC can be taken in consideration under well-defined conditions, as transmission rate appears to be high and so is the morbidity. There is no international consensus on the predictive value and cost-effectiveness of surveillance culture from donor at the time of donation or culture of the preservation fluid. Clinical experience and epidemiology should be taken into account when designing local policies.