Delayed Hemolytic Transfusion Reaction (DHTR), anti-Co(b)

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
16 days
Alerting signals, symptoms, evidence of occurrence: 
A patient with sickle cell disease received several red cell units during her pregnancy. Sixteen days after the initial 2-unit transfusion, she reported to the clinic complaining of pain in her legs and right arm. Blood samples submitted to the blood bank at this time revealed a positive antibody screen and autocontrol. The direct antiglobulin test was positive. She showed a marked decrease in hemoglobin concentration.
Demonstration of imputability or root cause: 
A relatively strongly reactive anti-Co(b) at the antiglobulin phase was identified.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
Cotton blood group, Co(b),
Reference attachment: 
Suggest references: 
Squires JE, Larison PJ, Charles WT and Milner PF. (1985). A delayed hemolytic transfusion reaction due to anti-Cob. Transfusion 25:137-9
Expert comments for publication: 
The Cotton Blood Group system, anti-Co(a) causes acute and delayed hemolytic transfsuion reactions (HTRs). Anti-Co(b) and -Co3 have caused mild HTRs.