Status:
Ready to upload
Record number:
1545
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment for ovarian cancer (Council of Europe, 2022):
Ovarian cancer is considered an unacceptable risk for organ donation. Ovarian cancer in the donor history: Treated ovarian cancer is considered high-risk for organ donation. Depending on initial stage, grade, therapy and time of recurrence-free survival (> 5 years), the risk category might decrease individually.
Time to detection:
Approximately 6 months
Alerting signals, symptoms, evidence of occurrence:
Notification of center when the other recipient developed cancer (Notify record 1544); This patient had intermittent fevers. On workup, a mass was found in the retroperitoneum involving the iliac and aortic lymph nodes. Findings similar to other patient, who had donor-transmitted ovarian mucinous adenocarcinoma.
Demonstration of imputability or root cause:
Both kidney recipient from the same donor developed adenocarcinoma shortly after transplantation.The origin of the malignancy was confirmed from the other donor by Karyotyping in one of the recipients.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
References:
Suggest new keywords:
Ovarian cancer
Transplantectomy
Chemotherapy
Metastatic disease
Suggest references:
Lipshutz, G.S.; Mihara, N.; Wong, R.; Wallace, W.D.; Allen-Auerbach, M.; Dorigo, O.; Rao, P.N.; Pham, P.C.; Pham, P.T. Death from metastatic donor-derived ovarian cancer in a male kidney transplant recipient Am J Transplant 2009; 9 (2) :428 - 32
Expert comments for publication:
Two recipient from a donor without a history of ovarian cancer developed the same tumor and expired.