Human immunodeficiency virus (HIV)

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
34 days
Alerting signals, symptoms, evidence of occurrence: 
Serologic tests and NAT assay identified HIV-1 infection at 34 days after transfusion. The donor had tested positive for HIV in a subsequent donation of this unit. The recipient of the red blood cells from this donor tested negative.
Demonstration of imputability or root cause: 
HIV-1 transmission through fresh-frozen plasma (FFP) from one blood donor during the window period. The viral sequences determined in blood samples from both the donor and the FFP recipient differed by only one among 341 nucleotides in the env region (99.7% identity). Such high genetic similarity among the sequences supported the notion that HIV had been transmitted from the donor to the FFP recipient.
Imputability grade: 
3 Definite/Certain/Proven
Reference attachment: 
Suggest references: 
Sobata, R., Shinohara, N., Matsumoto, C., Uchida, S., Igarashi, S., Hino, S., Satake, M. and Tadokoro, K. (2014). First report of human immunodeficiency virus transmission via a blood donation that tested negative by 20-minipool nucleic acid amplification in Japan.Transfusion 54(9): 2361-2.