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Adverse Occurrence type:
Time to detection:
22 - 42 days
Alerting signals, symptoms, evidence of occurrence:
In one asplenic patient, infection presented as unremitting, high grade fever. Ring forms, intra-erythrocytic parasites seen in blood smear were initially diagnosed as Plasmodium spp; inoculation of hamsters resulted in isolation of Babesia microti. In the series described by Linden et al, other recipients, including neonates and elderly patients, had asymptomatic infection. One 44 day old term baby had fever. In all cases, retrospective testing of donor revealed positive antibody titres (IFA) and sometimes B.microti DNA positivity in blood, by PCR.
Demonstration of imputability or root cause:
Donors had history of exposure to ticks and were retrospectively found to be seropositive for Babesia microti. Recipients did not have positive history of travel to endemic areas in the USA nor exposure to animals or tick bites.
Lookback investigations of Babesia microti-seropositive blood donors: seven-year experience in a Babesia-endemic area.
Suggest new keywords:
Grabowski, E.F., Giardina, P.J., Godber, D., Masur, H., Read, S.E., Hirsch, R.L. and Benach, J.L. (1982). Babesiosis transmitted by a transfusion of frozen-thawed blood. Ann Intern Med 96(4): 466-7; Linden, J.V., Wong, S.J., Chu, F.K., Schmidt, G.B. and Bianco, C. (2000). Transfusion-associated transmission of babesiosis in New York State. Transfusion 40(3):285-289.
Add Babesia to the adverse occurrence taxonomy: Harm to a recipient/Infection/Parasitic/Babesia(Evi)