Status:
Ready to upload
Record number:
1315
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
There is only one known case of transfusion-transmitted Rocky Mountain Spotted Fever (Rickettsia rickettsii) published in the literature, so it is presumed to be very rare.
Time to detection:
6 days
Alerting signals, symptoms, evidence of occurrence:
Donor had onset of illness 3 days after whole blood donation; recipient became mildly ill after transfusion and fully recovered after appropriate antibiotic treatment (starting at the fourth day of illness).
Demonstration of imputability or root cause:
The donor reported tick removal 18 hours after a whole blood donation and subsequently died after 7 days. Organism was identified in the donor post-mortem. Diagnosis was confirmed in the donor by indirect fluorescent antibody (Rickettsia rickettsii was identified in several tissues), and in the recipient by antibody and isolation from blood (via inoculation in tissue and animal models).
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
References:
Suggest new keywords:
Rocky Mountain spotted fever
Rickettsia rickettsii
Reference attachment:
Suggest references:
Wells GM, Woodward TE, Fiset P, Hornick RB. Rocky Mountain spotted fever caused by blood transfusion. JAMA 1978;239:2763-5.
Note:
The Leiby et al paper is a review and should not be used as a primary reference. Use Wells paper from JAMA 1978. I cannot access the JAMA paper to obtain more details.
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ADD: Harm to a recipient/Infection/Bacterial/Rickettsia; ADD THE SECOND REFERENCE (WELLS ET AL) (Evi)