Acute Hemolysis following high dose IV immunoglobulin

Status:

Ready to upload

Record number:

1183

Adverse Occurrence type:

Acute Hemolytic Reaction

MPHO Type:

Plasma derivates

Estimated frequency:

Case report

Time to detection:

Following multiple courses ( four) of high dose IVIg therapy (400mg/Kg of body weight x 5 days)

Alerting signals, symptoms, evidence of occurrence:

Jaundice, palor, low grade fever, dark urine.

Demonstration of imputability or root cause:

High titer IgM anti-A antibodies in IVIg products

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Clinical complications

Keywords:

IVIG (intravenous immunoglobulin)

intravascular hemolysis

B cell lymphoma

References:

Acute intravascular haemolysis associated with high dose immunoglobulin after bone marrow transplantation for acute myelogenous leukemia

Reference attachment:

* AHTR IVIg, Rovelli, 1991.pdf

Suggest references:

Rovelli, A., D’Angelo, P., Balduzzi, A., Borzini, P., Blondi, A. & Uderzo, C. (1991) Acute intravascular haemolysis associated with high dose immunoglobulin after bone marrow transplantation for acute myelogenous leukemia. Leukemia and Lymphoma, 5, 71–74.

Note:

OK ONCE THE CORRECT REFERENCE IS INDEXED (EVI)

Expert comments for publication:

Interesting historic case report of anti-A (and anti-B) RBC alloantibodies in IVIg products presumably reflecting the antibody status of IVIg product donors. Warnig to group A and B patients receiving high dose IVIg products.