Febrile Non Hemolytic Reactions (FNHTR)

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
A total of 133,671 transfusions were performed at University Medical Center (VUMC) during the study period including 20,179 platelet (PLT) transfusions, 31,605 plasma transfusions, 79,933 red blood cell (RBC) transfusions, and 2154 cryoprecipitate transfusions. Over the same period, 108 pediatric and 277 adult transfusion reactions were recorded. This corresponds to an incidence of 6.2 reactions per 1000 transfusions within the pediatric (age < 21) population and an incidence of 2.4 reactions per 1000 transfusions within the adult population. Within the pediatric population, subset analysis identified multiple differences when compared to the adult population, including an increased incidence of allergic transfusion reactions (2.7/1000 vs. 1.1/1000, p < 0.001), febrile nonhemolytic transfusion reactions (1.9/1000 vs. 0.47/1000, p < 0.001), and hypotensive transfusion reactions (0.29/1000 vs. 0.078/1000, p < 0.05). Interestingly, while the reaction incidence was the same between sexes in adults, in pediatric patients, reactions were more common in male patients (7.9/1000 pediatric males vs. 4.3/1000 pediatric females, p < 0.01). Plasma pediatric reaction rate 0.150% of plasma transfusion and plasma adult reaction rate 0.152% of plasma transfusions at hospital during twenty-five months.
Alerting signals, symptoms, evidence of occurrence: 
Between the period of January 1, 2011, and February 1, 2013, all reported adult and pediatric transfusion reactions at VUMC were evaluated by transfusion medicine clinical service. Latency data are unavailable due to aggregate reporting, they are however evaluated using hemovigilance definitions.
Demonstration of imputability or root cause: 
Reported transfusion reactions varied according to type of transfusion reaction.
Imputability grade: 
Not Assessable
Groups audience: 
Suggest new keywords: 
transfusion reactions, hemovigilance defininitions, pediatric, adult, plasma
Suggest references: 
Oakley, F.O., Woods, M., Arnold, S. and Young, P.P. (2014). Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products. Transfusion