Olen - 29/09/2016 - 10:16

Adverse Occurrence type: 
MPHO Type: 
Estimates Frequency: 
The authors did not provide information about the number of organs transplanted from the donor.
Time to detection: 
Seven days after transplantation
Alerting signals, symptoms, evidence of occurrence : 
The recipient developed fever and respiratory distress with sputum and infiltrates on chest rx. The diagnosis was made by citologic examination of bronchial washings.
Demonstration of imputability or root cause: 
The recipient tested negative for Coccidioides serology and the explanted lungs and lymph nodes did not show the presence of coccidioidomycosis. On the other hand, Coccidioides immitis was observed in an hilar lymph node form the donor.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Revised due to lacking of imputability and expert comment.
Suggest new keywords: 
coccidioidomycosis, coccidioides immitis, lung transplantation, respiratory distress, fluconazole
Adverse occurrence description: 
Coccidioidomycosis donor-to-host transmission
Suggest references: 
Roy M, Park BJ, Chiller TM. donor-derived fungal infections in transplant patients. Curr Fungal Infect Rep 2010;4:219-28.
Expert comments for publication: 
Antifungal prophylaxis should be considered if either the donor or the recipient are suspected of being affected with coccidioidomycosis until infection can be securely discarded. Both serology and pathologic examination can not be immediately performed at transplantation.