Olen - 29/09/2016 - 00:05

Adverse Occurrence type: 
MPHO Type: 
Estimates Frequency: 
The authors do not provide information about the number of organs donated by the donor.
Time to detection: 
Two weeks after the procedure.
Alerting signals, symptoms, evidence of occurrence : 
The aatient complained for hypotension and hypoxia. He progressively developed renal and respiratory failure. He died one month after the transplantation. The autopsy confirmed disseminated coccidioidomycosis.
Demonstration of imputability or root cause: 
The recipient had never been in an endemic area. The donor visited Mexico two years prior to donation. However, serology for Coccidioides was not performed as both donor and recipient lived in a non-endemic area.
Imputability grade: 
2 Probable
Groups audience: 
Revised due to the lacking of imputability and expert comment.
Suggest new keywords: 
coccidioidomycosis, coccidioides immitis, lung transplantation, respiratory failure
Suggest references: 
Roy M, Park BJ, Chiller TM. donor-derived fungal infections in transplant patients. curr Fungal Infect Rep 2010;4:219-28.
Expert comments for publication: 
It is very important to ask for travel history. If the donor has travelled to an endemic area for cocciodioidomycosis, screening with serology should be performed. In the case there is no possibility or availability of serology is scarce but the suspicion is high, it is recommended to start fluconazole in the recipient until the results of serology are obtained.