When neoplasia is detected in the donor before or immediately after transplantation, histological examination and immunohistochemistry can help to identify the pathology for comparison with any subsequent tumors developing in the recipient or recipients. For example, identification of a lung carcinoma in the donor needs detailed investigation of the tumor (histology, grade and immunohistochemical profile) and either graft removal or careful follow up of the recipients. If a tumor develops in one or more of the recipients of organs from this donor, the morphological comparison of the tumor in the donor and the tumor arising in the recipients can confirm the donor origin of the tumor.
